NR4A1 and endometrial carcinoma: In order to classify for improving the EC prognosis, in 1983, Bokhman described two pathogenetic types of endometrial carcinomas characterized by different metabolic, morphological, and endocrine profiles: type 1 is more common (~70–80%) and consists of endometrioid histology and is low grade, diploid, hormone-receptor positive and typical of obese women, and type 2 (20–30%) consists of nonendometrioid histology, is high-grade, aneuploid, poorly differentiated, hormone-receptor negative and typical of nonobese women, and is associated with higher risk of metastasis and poor prognosis.