The percentage of subjects with asthma having hypereosinophilia and increased total IgE was significantly higher than that in COPD and ACO subjects (78.9% versus 5.4% and 64.4%, P < 0.001 and P < 0.05; 81.5% versus 27.0% and 45.7%, P < 0.001 and P < 0.01, resp.; Table 2). The gene discussed is IGHE; the disease is chronic obstructive pulmonary disease.