Hyperglycemia causes tissue and endothelial damage through five primary mechanisms: (1) increase in the flow of glucose through the activation of the alternative metabolic pathways of glucose, the polyol pathway; (2) increase in the formation of intracellular advanced glycation end-products (AGE); increase in expression of the AGE receptor and activation of the ligands; (4) activation of isoforms of the protein kinase C (PKC); and (5) hyperactivity of the hexosamine pathway [14] (Figure 1). Here, PRRT2 is linked to Hyperglycemia.