As a categorical variable (Table S4), high-serum MMP-8 ( > 100 ng/mL) was associated with higher TNM stage (p < 0.001), T-class (p = 0.001) and M-class (p < 0.001), lymphatic invasion (p = 0.001), blood vessel invasion (p = 0.004), positive BRAF VE1 immunohistochemistry (p = 0.012) and MMR deficiency (p = 0.050). This evidence concerns the gene MMP8 and hyperinsulinemic hypoglycemia, familial, 4.