A high association between AFP progression and radiographic progression occurring within each tumour assessment period was also observed (OR 6.4, 95% CI 4.0, 10.3, P < 0.0001 for up to Week 6, OR 2.3, 95% CI 1.5, 3.5, P = 0.0002 for Weeks 6–12) (Table 1). The gene discussed is AFP; the disease is neoplasm.