First, among dual therapies we could not examine protease inhibitor (PI) and integrase strand transfer inhibitor (INSTI)-based combinations separately (not many people received dolutegravir either); second, a median follow-up of 2 years could not allow us to evaluate either the persistence of this phenomenon or the impact of the strategies on the onset of non-AIDS events; third, we did not have more detailed immunological data than the counts themselves, and it would be extremely relevant to stratify the analysis according to specific CD8 subpopulations and CD38/HLDR+ expression. This evidence concerns the gene CD38 and AIDS.