Inflammatory cytokines including IL-6 and IL-8 are elevated in the cerebrospinal fluid (CSF) in PD compared in controls [6, 7], and immune alterations have been reported in peripheral blood including changes in monocyte [8] and lymphocyte subsets in PD [9, 10], which may be driven by a specific immune response to alpha synuclein [11]. This evidence concerns the gene CXCL8 and Parkinson disease.