Some laboratory parameters such as anemia, hypoalbuminemia, hypercalcemia, and high β2-microglobulin (β2M), C-reactive protein (CRP), creatinine (Cr), and lactate dehydrogenase (LDH) are also prognostically relevant in patients with MM [13,14,15,16,17]. This evidence concerns the gene B2M and Hypoalbuminemia.