The American Urological Association (AUA) guideline on early detection of prostate cancer does not advise screening in men younger than 40 or older than 70 years, or those with less than a 10-year life expectancy.13 The AUA and American Cancer Society (ACS) currently recommend that PSA testing be offered to asymptomatic men aged 55–69 years (AUA) or men older than 50 years with a minimum 10-year life expectancy (ACS) after patients receive information about the harms and benefits associated with screening.14 This evidence concerns the gene KLK3 and prostate cancer.