TP53 and neuroblastoma: Then, to assess if our genotoxic drugs at the doses reported above induced the stabilization of p53 in NB cell lines, the p53 wild type, ATM single copy LA-N-5 NB cell line was treated with cisplatin, etoposide, irinotecan, or topotecan for 2, 5, and 8 hours, and the level of p53 was evaluated by Western blotting.