Diffuse midline gliomas show histone mutations H3F3A K27, since hemispheric-G34 alterations are accompanied by ATRX mutations with loss of its tissue expression [21, 27, 30, 31]. IDH1 and IDH2 mutations are very rare in pediatric astrocytomas. The gene discussed is ATRX; the disease is astrocytoma (excluding glioblastoma).