A clinical study on chronic hepatitis B showed that serum levels of IL-37 in chronic hepatitis B patients with high viral load were significantly higher than those in normal population, and serum levels of IL-37 were increased in hepatitis B e antigen- (HBeAg-) positive chronic type B patients and were positively correlated with the virus concentration and ALT levels [39]. This evidence concerns the gene GPT and chronic hepatitis B virus infection.