This finding is not consistent with studies that found that the low-functioning BDNF Met66 allele and CM/childhood trauma or early life adversity or stress interact to predict increased susceptibility for psychopathology, including anxiety-related temperamental traits, such as neuroticism (Gatt et al., 2009) and guilt-proneness (Szentágotai-Tətar et al., 2015), anxiety symptoms (Gatt et al., 2009) and mood disorders and associated symptoms (Aguilera et al., 2009; Carver et al., 2011; Gutiérrez et al., 2015). The gene discussed is BDNF; the disease is Anxiety.