Mantle cell lymphoma (MCL) cells with wild-type p53 status treated with only Nutlin-3 showed increased levels of p53 and activated p53 (p-ser15-p53), which induced phosphorylation of AMPK and decreased phosphorylation of rpS6, 4E-BP1, p70S6K and AKT. This evidence concerns the gene AKT1 and mantle cell lymphoma.