Proteomic analysis of breast carcinoma cell lines expressing mutants p53A278P, p53R280K or p53M385T treated with Prima1-met, showed differential expression of Annexin A1, Annexin A2, bifunctional methylenetetrahydrofolate dehydrogenase (MTHFD2), L-lactate dehydrogenase (LDH), GAPDH, malate dehydrogenase (MDH2) and voltage-dependent anion-selective channel protein 2 (VDAC2). The gene discussed is PHGDH; the disease is breast carcinoma.