Prima1 and Prima1-met (APR-246) are small molecules that rescue mutant p53 activity [435, 436], there are already early phase 1 clinical trials using Prima1-met for Esophageal carcinoma, acute myeloid leukemia, myelodysplastic syndrome and myeloproliferative neoplasm (ClinicalTrials.gov identifiers: NCT02999893, NCT03072043). This evidence concerns the gene PRIMA1 and myeloproliferative disorder.