GPT and interstitial lung disease: There were eleven ≥ grade 3 AEs (three ALT increased, one AST increased, one retinal detachment, one case of interstitial lung disease, one creatine phosphokinase increased, one hypoalbuminemia, one case of anemia, one white blood cell count decreased, and one neutrophil count decreased) experienced by eight of the 15 patients (53.3%).