GPT and retinal detachment: Dose interruptions were reported in seven patients who received 400 mg, 600 mg, or 800 mg DS-6051b and were due to grade 3 ALT increased (n = 2), grade 2 ALT increased (n = 1), grade 2 AST increased (n = 1), grade 2 pneumothorax (n = 1), grade 3 retinal detachment (n = 1), grade 4 creatine phosphokinase increased (n = 1), or grade 4 neutrophil count decreased (n = 1).