According to top 3 TFs with the largest differences between two datasets in AML+nok/abn (Figure 3C) and in MDS (Figure 3D) including the apoptosis-related TF FOXO3a, the anti-apoptosis-related TF NF-κBs, the angiogenesis-related TF HIF-1α, the cell cycle-related TF E2Fs, and the differentiation-related TF PU.1, the TFs also have large differences between AML+nok/abn and MDS in the same dataset (Figure 3B). The gene discussed is FOXO3; the disease is myelodysplastic syndrome.