Therefore, we inferred that the 5 TFs FOXO3a, NF-κBs, HIF-1α, E2Fs and PU.1 with the largest differences in transductivity sensitivity result from the effect of individual difference on the induction of redundant cellular functions such as anti-apoptosis, angiogenesis, cell cycle and cell differentiation to promote AML/MDS leukemogenesis. The gene discussed is HIF1A; the disease is acute myeloid leukemia.