We select seven proliferation-related TFs (CSLs, p300, CTBPs, AP-2α, STATs, c-Jun and β-catenin), two apoptosis-related TFs (p53, FOXO3a) and three differentiation-related TFs (C/EBPα, AML1, and ETO), the critical TFs to integrate signals from multiple pathways to transcriptionally regulate target genes in Supplementary Figure 1, to discuss their gain or lose cellular functions in leukemia using transductivity sensitivity, basal sensitivity, and error sensitivity. The gene discussed is RUNX1; the disease is leukemia.