As shown in Figures 3B and 4B, two apoptosis-related TFs (p53, FOXO3a) integrate signals from the PI3K-AKT, JNK MAPK and p38 coupling pathways and PI3K-AKT and TNFα-NIK coupling pathways to repress apoptosis in AML subtype. The gene discussed is TNF; the disease is acute myeloid leukemia.