SPHK1 and glioblastoma: For example, the upregulation of BNIP3, MMP3, MMP7, MMP15, TGFBI, NOTCH2, AKT1, AKT3, TNFAIP3, RRM2, CXCL8, FOXM1, HMOX1, PRMT5, KDM2B, CERS6, SPHK1, ZBTB18, and PDK1 have been linked to radioresistance and increased aggressiveness of irradiated GBM cells [20–40].