For example, the upregulation of BNIP3, MMP3, MMP7, MMP15, TGFBI, NOTCH2, AKT1, AKT3, TNFAIP3, RRM2, CXCL8, FOXM1, HMOX1, PRMT5, KDM2B, CERS6, SPHK1, ZBTB18, and PDK1 have been linked to radioresistance and increased aggressiveness of irradiated GBM cells [20–40]. The gene discussed is PDK1; the disease is glioblastoma.