Herein, as a potential mechanism for its radio- and chemosensitizing activity, we demonstrate for the first time that RRx-001 targets cancer stem cells (CSCs) and that it decreases the expression levels of Wnt pathway components and target genes, such as TCF4, Pygo2, Axin2 and c-Myc, which are known to govern stem cell renewal and differentiation [7, 8]. Here, MYC is linked to cancer.