SLC3A2 and neoplasm: In fact, it is reported that high CD98hc immunoreactivity correlates with high LAT1 expression [45]; moreover, overexpression of LAT1 light chain and CD98hc plays an important role in the progression and metastasis of several human neoplasms since the level of both chains increase markedly in the metastatic sites compared with the primary sites of the tumor [46].