CASP3 and cervical cancer: This is in agreement with several reports such as the work of Keawpradub et al. reporting that berberine has a low antioxidant activity (EC50 > 100 μg/mL) [34] and the work on the CaSki human cervical cancer line, where Lin et al. found that berberine has an oxidizing activity by increasing the levels of ROS (reactive oxygen derivatives) that destabilizes the potential mitochondrial membrane, thereby dropping cytochrome C in the cytosol that will go into the activation of caspase-3, eventually causing the phenomenon of apoptosis [35].