CD8A and cancer: But in a study Shahid et al mentioned that NHL is the four times more common cancer in the males as compare to females which is 6.1% in Pakistan.23 In our study, there were only two cases of non-Hodgkin lymphoma and both showed aberrant expression of CD8 marker which is in line with study by Carulli et al.24 The significance of CD8 as prognostic marker is still under debate with contradictory studies on its association with aggressive form of disease.