Homozygous deletion of LRP1B has been reported in multiple malignancies, namely esophageal cancer, glioblastoma, and cervical cancer.25, 26, 27LRP1B gene has been recently identified as the integration site for HPV in cervical and oropharyngeal cancers.27, 28 The TRAF3 gene encodes a cytoplasmic adaptor protein, with E3 ligase activity, which is involved in the signaling of a variety of adaptive and innate immune receptors as well as cytokine receptors. Here, TRAF3 is linked to esophageal cancer.