LRP1B and cancer: Bi‐allelic inactivation of TGFBR2 using a keratin 14 promoter in mice leads to spontaneous genital and anal SCC.20 Homozygous deletion of TGFBR2 has been reported in gastric and pancreatic cancer,21, 22 and alteration of TGFBR2 expression is associated with poor prognosis in several cancers.23, 24 The LRP1B gene encodes a member of the LDL receptor family of lipoprotein receptors that is involved in cholesterol metabolism and atherosclerotic lesion formation.