TRAF3 and B-cell chronic lymphocytic leukemia: In particular, homozygous deletions of the TRAF3 gene have been detected in hematopoietic malignancies, such as multiple myeloma, non‐Hodgkin lymphoma, and B‐cell chronic lymphocytic leukemia.29, 30TRAF3 has recently been shown to be downregulated by HPV via upregulation of UCHL1 with suppression of the innate immune response in keratinocytes.31