Insulin itself could be oncogenic,30 and results from several analyses showed that people with hyperinsulinaemia were at increased risk of breast and colorectal cancer irrespective of their BMI.31, 32, 33 Prospective studies and large-scale consortia with more accurate assessments of adiposity, diabetes, and metabolic health, which incorporate molecular tools, will be needed to draw conclusions about the underlying mechanisms that link diabetes, high BMI, and cancer, and inform clinical interventions. This evidence concerns the gene INS and diabetes mellitus.