However, since Orai1 and STIM1 are involved in ARC as well as in SOCE [49], and the down-regulation of one of more of these components [50] or proteins that interact with them [51, 52] may protect tumour cells from apoptosis, dynamic modelling approaches are needed to clarify how such signalling processes interact in the context of cell differentiation and tumour biology. This evidence concerns the gene ORAI1 and neoplasm.