STIM1 and neoplasm: However, since Orai1 and STIM1 are involved in ARC as well as in SOCE [49], and the down-regulation of one of more of these components [50] or proteins that interact with them [51, 52] may protect tumour cells from apoptosis, dynamic modelling approaches are needed to clarify how such signalling processes interact in the context of cell differentiation and tumour biology.