TGM2 and pulmonary arterial hypertension: This seemingly partial inhibition of TG2 might be due to the limited TG2 inhibitory potency of ERW1041E (Ki: 11 μM [23]) compared with compound 2, although previously it has been shown that this compound was able to at least partially inhibit intestinal TG2 in a mouse model [8] and also in a mouse model of pulmonary hypertension to baseline levels [9].