The amounts of glucocorticoid receptor (GR), 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), phosphoenolpyruvate carboxykinase (PEPCK), and SREBP-1c mRNAs were increased in the liver of the MetS group in a manner sensitive to inhibition by the low dose of HK L-137 (Fig. 11D–G). This evidence concerns the gene PCK2 and metabolic syndrome.