To examine whether the avirulence of C. deuterogattii ire1Δ and hxl1Δ mutants is caused by reduced cell survival similar to C. neoformans ire1Δ and hxl1Δ mutants24, we measured fungal burden in the lungs and brains recovered from mice at day 14 post infection. The gene discussed is ERN1; the disease is infection.