The ARVC/D Genetic Variants Database listed 364 pathogenic and 266 unknown variants across the five major ARVC genes: PKP2, DSP, DSG2, DSC2 and JUP. The majority of different pathogenic variants were reported in the PKP2 gene (n = 171) (summarised in Table 1). This evidence concerns the gene JUP and Arrhythmogenic right ventricular dysplasia.