The gnomAD database contained in total 8407 different variants (including common variants located in the untranslated regions, captured intronic and synonymous changes) located in the five ARVC genes, with PKP2 having the highest number of variants per amino acid (1.60), and DSP being at the opposite end with 1.06 variants per amino acid (Table 1). This evidence concerns the gene DSP and arrhythmogenic right ventricular cardiomyopathy.