The genome Aggregation Database (gnomAD) population of 138,632 unrelated individuals was searched for previously identified ARVC variants, classified as pathogenic or unknown on the disease genetic variant database (http://www.arvcdatabase.info/), in five most-commonly mutated genes: PKP2, DSP, DSG2, DSC2 and JUP, where variants account for 40–50% of all the ARVC cases. The gene discussed is DSG2; the disease is arrhythmogenic right ventricular cardiomyopathy.