Finally, we tried to maintain acinar cell enhancers by expressing acinar cell-specific TFs (Ptf1a or Mist1) in caerulein-treated KC mice, in which caerulein-induced inflammation initiates ADM/PanIN formation and activates ERK signaling (Fig. 5f and Supplementary Fig. 4E). Here, PTF1A is linked to keratoconus.