Transcriptomic profiling of cells from myeloma patients has shown that a significant fraction of up-regulated transcripts encode proteins that are involved in RNA processing and degradation, e.g. PATL2 (protein associated with topoisomerase II homologue 2; RNA binding), DHX58 (DExH-Box Helicase 58; RNA helicase), PAN2 (PolyA-Specific Ribonuclease Subunit) and POP1 (Processing of Precursor 1; deadenylases), APOBEC3F (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3F; RNA editing) and RNU11 (RNA, U11 Small Nuclear; spliceosomal subunit) [37]. The gene discussed is PAN2; the disease is plasma cell myeloma.