In rheumatoid arthritis (RA), for example, it has been shown that various inflammatory cytokines including TNF-α, IL-1, and IL-6 are involved in joint inflammation and that T cells interact with tissue-resident macrophage-like or fibroblast-like synoviocytes (FLSs) in destroying cartilage and bone in the joint (Bartok and Firestein, 2010). This evidence concerns the gene IL6 and rheumatoid arthritis.