RPIA and infection: Glucose-6-phosphate isomerase has been studied as a target for infections caused by Plasmodium falciparum [96], Trypanossoma spp [97], Toxoplasma gondii [98], and Leishamania ssp [99], acetyl-CoA carboxylase for L. major [100, 101], and ribose 5-phosphate isomerase in other organisms [102].