To further understand the pathological changes in neuronal cells after 30 min BCCAO, we examined brain samples using transmission electron microscopy (TEM) in sham, I-R induced rats 8 h after reperfusion, a time sufficient for damage to occur and A2A antagonist administered prior to cerebral ischemia and 8 hours after reperfusion. The gene discussed is IGKV2D-29; the disease is brain ischemia.