KRAS and acute lymphoblastic leukemia: We observed widespread phosphorylation of Akt (pAkt) in T-ALL cells with either RasGRP1 overexpression or an oncogenic Kras mutation and in human Jurkat and MOLT-3 T-ALL cell lines, yet with heterogeneous intensity and different patterns of activation either at baseline and/or following cytokine stimulation (Fig 1A–1C).