PTPRC and steatosis: Although in control livers, B220+ plasma/B-lymphocytes and CD3+ lymphocytes were rare and randomly dispersed, in PTENLKO livers, B220+ lymphocytes and CD3+ lymphocytes were abundant in regions of ductular responses and throughout areas of increased steatosis (Fig 2C, 2D, 2G & 2H arrows), verifying that there are both innate and adaptive immune responses in areas around proliferating cholangiocytes in PTENLKO livers.