Consistently, our recent study [30] identified the existence of a safeguard mechanism of p53-mediated demethylation against Enhancer of Zeste Homolog 2 (EZH2)-mediated methylation of H3K27 at the CDH1 locus, which induces CDH1 expression in certain cancer cells and organizes them into sheet structures via E-cadherin-mediated cell–cell interactions. Here, CDH1 is linked to cancer.