Treatment of colon cancer cells with 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARγ, arrests the growth of colon cancer cells via a PPARγ dependent pathway involving increased expression of KLF10 and decreased Bcl-2 (B cell lymphoma 2) expressions [72]. The gene discussed is PPARG; the disease is malignant colon neoplasm.