Therefore, the present work was performed, for the first time to the best of our knowledge, to analyze the prevalence and severity of depression, and their potential factors and predictors in the subjects with different genotypes of TNF-RII rs1061622 among adolescent survivors longitudinally at 6, 12, and 18 months after the Wenchuan earthquake. This evidence concerns the gene TNFRSF1B and depressive disorder.