It has been reported in the literature that α-solanine acts as an antitumor agent in inhibition of Wnt/β-catenin, Akt/mTOR, Stat3 and NF-κB pathways in non-toxic concentrations in healthy cells and in pancreatic cancer cells (PANC-1) [21]. Here, STAT3 is linked to familial pancreatic carcinoma.