Recently, Pallotta et al. [121] proposed a model of bioengineered cardiac tissues preconditioned with BMPs—proteins usually secreted by macrophages present at the site of myocardial infarction—that improved CMs functionality, cardiac gene expression and the ability to sustain angiogenesis in vitro based on diffusion of the exogenous BMPs. This evidence concerns the gene CLN5 and myocardial infarction.