TGFB1 and neoplasm: The pro-cancer progression consequences of aberrant TGF-β1 pathway signaling impacts virtually all cell types in the tumor microenvironment and involves redirected stromal remodeling, promotion of tumor cell plasticity (facilitating migration, invasion and metastasis), stimulation of angiogenesis, induced immunosuppression with loss of immunosurveillance and resistance to the TGF-β1-driven apoptotic and cytostatic programs [31].