Interestingly, the secretion of exosomal microRNA (miRNA) can be regulated by the neutral sphyngomyelinase 2 (nSMase2), the release of exosomes was reduced after inhibiting the activity of nSMase2 with GW4869, and overexpression of nSMase2 increased extracellular amounts of miRNAs, hypoxia promoted exosomes release along with exosomal miRNA increase, while some drugs could inhibit exosome secretion.61, 62, 63 These findings indicate that the generation and secretion of exosomes are of modulation and selectivity, and whether this property could be used for cancer therapy needs deeper study. This evidence concerns the gene SMPD3 and cancer.