HIF turns on genes including those that regulate cancer metabolism (GLUT-1, PDK, MCT-4, and LDHA), anigiogenesis (VEGF, PDGF), epithelial-mesenchymal transition (SNAIL, ZEB), and metastasis (PLOD2, LOXs, MMPs, ANGPTL4, and L1CAM)12. Here, PLOD2 is linked to cancer.