TNNI3 and Abnormal renal physiology: Analogously, the specificity was improved in patients with renal dysfunction (defined as eGFR < 60 ml/min/1.73 m2) from 0.83 (95% CI 0.74–0.90) and 0.77 (95% CI 0.68–0.85) to 0.95 (95% CI 0.89–0.98) and 0.86 (95% CI 0.78–0.92) in males and females, respectively, using adjusted cs-cTnI values instead of raw values (Supplementary Table 10).