We also demonstrated that the Rad21 influences the expression of XPO1, CyclinB1, CDK1, P21, P27 and P53 through up‐ and downregulating the Rad21 expression, hence suggesting that the Rad21 gene promotes the development of cervical cancer possibly by participating in the regulation of cell cycle and the nuclear output of the tumor suppressor gene by XPO1. Here, TP53 is linked to cervical cancer.