IL33 and neoplasm: IL‐33, a member of the IL‐1 family, is secreted by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells and epithelial cells.13 Binding of IL‐33 to its receptor ST2 induces the activation of NF‐κB and Th‐2 pro‐inflammatory cytokines, such as IL‐4, IL‐5 and IL‐13,14, 15 which play important roles in the development of OS.16, 17 Epithelial‐derived IL‐33 can promote tumorigenesis and metastasis both in vivo and in vitro.18, 19, 20 These findings implied that IL‐33 may be tumour‐associated pro‐inflammatory cytokine.