The surface enolase (eno) of bacteria, a glycolytic pathway enzyme, can bind human plasminogen and convert it into active plasmin (Cork et al., 2009) to facilitate bacterial adherence to host cells and destruction of host tissues through plasmin degrading intercellular junctions and extracellular matrix components (Attali, Durmort, Vernet, & Di Guilmi, 2008), like cellulitis (Bachmeyer et al., 2008), necrotizing fasciitis (Crum‐Cianflone, Matson, & Ballon‐Landa, 2014), and make the bacterial infection life‐threatening (Cork et al., 2009). The gene discussed is PLG; the disease is cellulitis.