Given the functional role of BCAM, NECTIN2, TOMM40, APOE, and APOC1 genes and the regulatory activity of variants in these genes, the molecular signatures elucidated in the present study could be associated with increased risk of developing an AD by increasing susceptibility to brain infections (Itzhaki et al., 2016; Porcellini, Carbone, Ianni & Licastro, 2010). Here, APOE is linked to Alzheimer disease.