There was also a significant difference in gender distribution between the two groups (6% males in FTA/AFTA group versus 38% males in FTC group, p < 0.001), which was not observed in Cohort A. Pooled multivariate analysis of Cohort A + B showed consistent results with analyses of Cohort A only, with Ki-67-index and tumor size identified as independent predictors of FTC (Supplementary Table 2). This evidence concerns the gene MKI67 and neoplasm.