Subsequent analysis of Cohort B (n = 109) verified the results from Cohort A. The FTC group had a significantly higher median Ki-67 index (p = 0.003), tumor size (p = 0.010) and age at diagnosis (p = 0.011) as compared to FTA or AFTA when pooling Hürthle cell tumors together with non- Hürthle cell tumors (Supplementary Figure 3). This evidence concerns the gene MKI67 and neoplasm.