Recent studies have shown that CLIC1 is present in various tumor tissues, and demonstrated the expression and role of CLIC1 during tumor development in various cancers, including gastric cancer [9-11], colonic cancer [8, 12], hepatic cancer [13-15], gallbladder cancer [16, 17], pancreatic cancer [18], lung cancer [19], prostate cancer [20], ovarian cancer [21, 22], and glioblastoma [23]. This evidence concerns the gene CLIC1 and gallbladder cancer.